Research of Mangifera indica L. antifungal activity in different Candida ssp. species associated with vulvovaginal candidiasis.
Oliveira K. M. S. de, Silva R. S. da, Cavalcante G. M.
Author Affiliation: Centro Universitário Cesmac, Maceió - AL, Brazil.
Arquivos de Ciências da Saúde da UNIPAR 19 : 179-183
Abstract : Vaginal Candidiasis is the most common and important opportunistic fungal infection in women. The increased use of antifungal drugs in recent years has caused resistance to the drugs available for treatment. The aim of this study was to investigate the antifungal activity of Mangifera indica on strains associated to vaginal candidiasis. In-vitro tests were conducted with crude extract and organics fractions against strains of Candida albicans (URM 4385), Candida glabrata (URM 4264) and Candida tropicalis (URM 4262), a courtesy of the Federal University of Pernambuco (UFPE), through diffusion in agar-bem assay and minimal inhibitory concentrations (MIC). The ethanolic extract was the most active, with inhibition diameter ranging between 25.5 to 18.5 mm, values that are similar to the standard drug, not presenting statistic different. The MIC varied from 0.04 to 0.16 mg/ml for the tested microorganism. The ethyl and methanolic acetate organic fractions presented relevant antifungal activity against C. glabrata and C. albicans, respectively. The chemical study for the extraction and isolation of active compounds is recommended for in-vitro assays of these compounds to investigate the antimicrobial activity.