Antihyperglycaemic effect of Mangifera indica in rat.
Aderibigbe A. O., Emudianughe T. S., Lawal B. A. S.
Author Affiliation: Department of Pharmacology and Therapeutics, Faculty of Health Sciences, University of Ilorin, Ilorin, Nigeria.
Phytotherapy Research 13 : 504-507
Abstract : Leaves of M. indica are used as an antidiabetic agent in Nigerian folk medicine. To determine whether or not there is a scientific basis for this use, the effect of the aqueous extract of leaves on blood glucose level was assessed in normoglycaemic, glucose-induced hyperglycaemic and streptozotocin (STZ)-induced diabetic rats. The aqueous extract (1 g/kg, p.o.) did not alter blood glucose levels in either normoglycaemic or STZ-induced diabetic rats. In glucose-induced hyperglycaemia, however, antidiabetic activity was seen when the extract and glucose were administered simultaneously and also when the extract was given to the rats 60 min before glucose. The extract exhibited hypoglycaemic properties which may be due to an intestinal reduction of the absorption of glucose.