Anti-tumor promoting activity of some Malaysian traditional vegetables (Ulam).
Mooi L. Y., Ali A. M., Norhanom A. B., Salleh K. M., Murakami A., Koshimizu K.
Author Affiliation: Department of Biotechnology, Faculty of Food Science and Biotechnology, Universiti Putra Malaysia, 43400 Serdang, Selangor, Malaysia.
Natural Product Sciences 5 : 33-38
Abstract : Ethanolic extracts of different parts of 10 traditional Malaysian vegetables (Amaranthus gangeticus [A. tricolor], Jussiaea linifolia [Ludwigia linifolia], Eugenia polyantha, Trapa incisa, Trichosanthes anguina [T. cucumerina], Mangifera indica, Pachyrhizus erosus, Barringtonia macrostachya, Carica papaya, and Coleus tuberosus Benth [Plectranthus parviflorus]) were screened for in vitro antitumour-promoting activity using the inhibition of Epstein-Barr virus (EBV) activation in Raji cells induced by phorbol 12-myristate 13-acetate and sodium-n-butyrate. All the extracts showed strong inhibitory activity towards EBV-activation, except for the leaf extract of T. anguina. The extracts were non-cytotoxic to the Raji cells except for the extracts of A. gangeticus (leaves), B. macrostachya (leaves), E. polyantha (young leaves), and J. linifolia (leaves) which significantly reduced cell viability.