Rehabilating activity of mangiferin in Benzo(a)Pyrene induced lung carcinogenesis.
Peramaiyan Rajendran, Ramachandran Venugopal, Ganapathy Ekambaram, Arumugam Aadithya, Dhanapal Sakthisekaran
Author Affiliation: Department of Medical Biochemistry, Dr. ALM PG Institute of Basic Medical Sciences, University of Madras, Taramani Campus, Chennai, 600 113, India.
Asian Journal of Biochemistry 3 : 118-125
Abstract : Cancer chemoprevention involves the prevention, delay or reversal of carcinogenesis through ingestion of dietary or pharmaceutical agents. A large number of potential chemopreventive agents are known, some of which have proven effective in clinical trials. These agents may function in a variety of mechanisms, directed at all major stages of carcinogenesis. One mechanism involves the inhibition of biosynthesis of polyamines such as spermine, spermidine and putrescine. In the present study, we evaluated the chemopreventive efficacy of mangiferin against Benzo(a)Pyrene (B(a)P) induced lung carcinogenesis in male Swiss albino mice strains. Lung carcinoma was induced with B(a) P (50 mg/kg body weight, orally). Treatment was started by oral administration of mangiferin (100 mg/kg body weight). The modulatory effect of mangiferin was examined on lung and liver to evaluate the level of polyamines, protein carbonyl, nucleic acid content and lipid peroxidation. Mangiferin significantly decreased the levels of polyamines, protein carbonyl, nucleic acid content and lipid peroxidation, which increased in lung cancer bearing animals. In conclusion, mangiferin could effectively inhibit B(a)P-induced lung carcinogenesis in albino mice by offering protection from protein damage and also by suppressing cell proliferation.