Standardised Mangifera indica extract is an ideal antioxidant.
Ling LaiTeng, Yap SuAnn, Radhakrishnan A. K., Thavamanithevi Subramaniam, Cheng HweeMing, Palanisamy U. D.
Author Affiliation: Department of Physiology, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia.
Food Chemistry 113 : 1154-1159
Abstract : The standardised ethanolic and aqueous extracts of Mangifera indica leaf were prepared and analysed for their free radicals scavenging activity. The IC50 values using the DPPH assay were 0.17±0.02 and 0.49±0.4 mg/ml, respectively. Standardised ethanolic extracts of the M. indica leaf had a solid content of 9.1±0.7%, mangiferin concentration of 73±0.17 mg/g of dry weight of the extract, free radical scavenging activity (IC50) of 0.17±0.02 mg/ml and total phenolic content of 590±48 mg/g of extract. The protection exhibited by these extracts against lipid peroxidation was superior to butylated hydroxytoluene (BHT) and commercial grape seed extract. These extracts at higher concentration did not exhibit pro-oxidant activities when compared to vitamin C. Our findings also show that the aqueous and ethanolic extracts of M. indica leaf protect NIH/3T3 cells from oxidant-induced cell death.