Antioxidant activity of some agro-industrial peels on liver and kidney of rats exposed to oxidative stress.
El-Ghany M. A. A., Ramadan M. A., Hassanain S. M. M.
Author Affiliation: Department of Home Economics, Faculty of Specific Education, Mansoura University, Egypt.
World Journal of Dairy & Food Sciences 6 : 105-114
Abstract : Forty-nine adult albino male rats Sprague-Dawley strain were randomly classified into six groups (7 rats each). The first group served as normal control group, fed on standard diet only. The other five groups were fed on standard diet and received 0.4 g/l of potassium bromate and 0.5 g/l cadmium chloride in drinking water and 5 g/kg body weight/24 h of ethanol in diet for four weeks to induce oxidative stress in liver and kidney. Then, rats reclassified into 5 groups which were positive control (untreated) and treated rat groups that were mango, apple, potato and mixture peels groups. The treatment period is designed for four weeks. The results revealed that, positive control group showed only a significant increase in food efficiency ratio, serum alanine and aspartate amino transferase (ALT & AST), alkaline phosphatase (ALP) enzymes activity, albumin/globulin ratio (A/G), uric acid, creatinine, urea, malondialdehyde (MDA), cholesterol, triglyceride, low density lipoprotein cholesterol (LDLc), very low density lipoprotein cholesterol (VLDLc) and cholesterol/high density lipoprotein cholesterol (HDLc) but a significant decrease in packed cell volume (PCV), white blood cells (WBCs), hemoglobin (Hg) and red blood cells (RBCs), total protein (TP), globulin, superoxide dismutase (SOD), glutathione peroxidase (GSP), catalase, HDLc in comparing with normal control group. Mango group showed a significant decrease in weight gain %, Hg, PCV, SPD and GSP but showed a significant increase in albumin, MDA, cholesterol and LDLc, while apple group showed a significant decrease in final weight, F