A novel binding agent for pharmaceutical formulation from Mangifera indica tree.
Nayak R. K., Swamy V. B. N., Shantesh Masurkar, Rahul Raut, Jismon Jose, Mahin M. M.
Author Affiliation: Department of Pharmaceutics, Karavali College of Pharmacy, Mangalore - 575 028, Karnataka, India.
Asian Journal of Biochemical and Pharmaceutical Research 2 : 194-215
Abstract : Plant gums and mucilage are being used in Pharmaceuticals and in other various industries due to their abundance in nature, safety and low cost. Binding agents are used to impart the structural strength required during the processing, handling and packaging of tablets. No significant work has been reported on Mangifera indica gum to use it as a tablet binder. Gum extracted from Mangifera indica was subjected to toxicity studies for its safety and preformulation studies for its suitability as a binding agent. The gum was evaluated for its granulating and binding properties in tablets, using lornoxicam as a model drug. Properties of the granules prepared with lornoxicam using five different concentrations (2, 4, 6, 8 and 10% w/v) of Mangifera indica gum and compared with starch (10%, w/v), as standard binder. The prepared granules were evaluated for percentage of fines, average particle size, total porosity, compressibility index and flow properties. The tablets were prepared and evaluated for content uniformity, hardness, friability, disintegration time and in vitro dissolution profiles. The tablets had good physicochemical properties, and the drug release was more than 90% within 90 min. The tablets prepared by using 10% gum as binder exhibited more hardness than by using 2, 4, 6 and 8% w/w gum concentration. At 6% concentration it has given similar disintegration time and dissolution profile in comparison to starch at 10% w/v. Hence, Mangifera indica gum at 6% w/v concentrations can be considered as ideal concentrations for preparation of tablets.