?-Glucosidase inhibitory potential of selected anti-diabetic plants used in North-Western Nigeria.
Andrew O., Yusuf S., Jangabe L. M., Lawal B. S., Adamu A. A.
Author Affiliation: Department of Biochemistry, Usmanu Danfodiyo University, P.M.B. 2346 Sokoto, Nigeria.
Journal of Medicinal Plants Research 7 : 2010-2018
Abstract : ?-Glucosidase inhibitory potential of selected anti-diabetic plants has been studied. The study evaluated ?-glucosidase inhibition using ?-glucosidase from Saccharomyces cerevisiae and p-nitrophenyl ?-D-glucopyranoside as substrate. The result showed that the extract of Albizzia chevalieri leaf, Khaya senegalensis stem bark, Zizypus spina-christi stem bark, Arachis hypogea seed varieties and Mangifera indica leaf had significant (P0.05) ?-glucosidase inhibitory effect in a concentration dependant manner as compared to acarbose. Cardiac glycosides, alkaloids, saponins, flavonoids and tannins were identified in the extracts. The study concludes that the plant extract contain bioactive compound that may be source(s) of lead compounds with ?-glucosidase inhibitory potentials and may explain their hypoglycaemic effects.